Monitoring of telomere dynamics in peripheral blood leukocytes in relation to colorectal cancer patients' outcomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00568783" target="_blank" >RIV/68378041:_____/22:00568783 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/22:10448649 RIV/00216208:11110/22:10448649 RIV/00064190:_____/22:N0000042

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fonc.2022.962929/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fonc.2022.962929/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fonc.2022.962929" target="_blank" >10.3389/fonc.2022.962929</a>

Result language

angličtina

Original language name

Monitoring of telomere dynamics in peripheral blood leukocytes in relation to colorectal cancer patients' outcomes

Original language description

We investigated the possible associations between leukocyte telomere length, therapy outcomes, and clinicopathological features in patients with colorectal cancer. Additionally, telomerase reverse transcriptase (TERT) expression was evaluated. Telomere length was measured using singleplex qPCR in 478 consecutive leukocyte DNA samples from 198 patients. Blood was drawn at diagnosis prior to any therapy and then at 6-month intervals for 18 months. Following diagnosis, the telomeres gradually shortened during the course of the treatment regardless of the patient's age. The most pronounced decrease was observed 12 months after the diagnosis (p < 0.0001). Based on tumor localization, the decrease in telomere length one year after the diagnosis followed different trajectories (p = 0.03). In patients treated with adjuvant therapy, telomere length correlated with the time elapsed after completion of therapy (p = 0.03). TERT expression did not correlate with the telomere length, however, it was higher in women than men (1.35-fold, 95% CI 1.11-1.65, p = 0.003) and in smokers than non-smokers (1.27-fold, 95% CI 1.01-1.61, p = 0.04). Leukocyte telomere length declines naturally during aging, but the accelerated shortening observed in our patients was age-independent. Telomere length manifestly reflected chemotherapy impact and could be linked to therapy toxicity.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Oncology

ISSN

2234-943X

e-ISSN

2234-943X

Volume of the periodical

12

Issue of the periodical within the volume

sep.

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

962929

UT code for WoS article

000874117100001

EID of the result in the Scopus database

2-s2.0-85139232904