Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00579203" target="_blank" >RIV/68378041:_____/23:00579203 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/23:10472516 RIV/00216208:11120/23:43926309 RIV/00064173:_____/23:43926309

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnbeh.2023.1321277/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnbeh.2023.1321277/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnbeh.2023.1321277" target="_blank" >10.3389/fnbeh.2023.1321277</a>

Result language

angličtina

Original language name

Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise

Original language description

Noise-induced tinnitus is generally associated with hearing impairment caused by traumatic acoustic overexposure. Previous studies in laboratory animals and human subjects, however, have observed differences in tinnitus susceptibility, even among individuals with similar hearing loss. The mechanisms underlying increased sensitivity or, conversely, resistance to tinnitus are still incompletely understood. Here, we used behavioral tests and ABR audiometry to compare the sound-evoked responses of mice that differed in the presence of noise-induced tinnitus. The aim was to find a specific pre-exposure neurophysiological marker that would predict the development of tinnitus after acoustic trauma. Noise-exposed mice were screened for tinnitus-like behavior with the GPIAS paradigm and subsequently divided into tinnitus (+T) and non-tinnitus (−T) groups. Both groups showed hearing loss after exposure, manifested by elevated audiometric thresholds along with reduced amplitudes and prolonged latencies of ABR waves. Prior to exposure, except for a slightly increased slope of growth function for ABR amplitudes in +T mice, the two groups did not show significant audiometric differences. Behavioral measures, such as the magnitude of the acoustic startle response and its inhibition by gap pre-pulse, were also similar before exposure in both groups. However, +T mice showed significantly increased suppression of the acoustic startle response in the presence of background noise of moderate intensity. Thus, increased modulation of startle by background sounds may represent a behavioral correlate of susceptibility to noise-induced tinnitus, and its measurement may form the basis of a simple non-invasive method for predicting tinnitus development in laboratory rodents.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Behavioral Neuroscience

ISSN

1662-5153

e-ISSN

—

Volume of the periodical

17

Issue of the periodical within the volume

dec.

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

1321277

UT code for WoS article

001128708900001

EID of the result in the Scopus database

2-s2.0-85180495374