Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00580369" target="_blank" >RIV/68378041:_____/23:00580369 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10456129
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S088723332200234X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S088723332200234X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tiv.2022.105536" target="_blank" >10.1016/j.tiv.2022.105536</a>
Alternative languages
Result language
angličtina
Original language name
Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells
Original language description
Nanoparticles (NPs) have a wide use in various field of industry and in medicine, where they represent a promise for their antimicrobial effects. Simultaneous application of NPs and therapeutic stem cells can speed up tissue regeneration and improve healing process but there is a danger of negative impacts of NPs on stem cells. Therefore, we tested effects of four types of metal antimicrobial NPs on characteristics and function properties of mouse mesenchymal stem cells (MSCs) in vitro. All types of tested NPs, i.e. zinc oxide, silver, copper oxide and titanium dioxide, exerted negative effects on the expression of phenotypic markers, metabolic activity, differ-entiation potential, expression of genes for immunoregulatory molecules and on production of cytokines and growth factors by MSCs. However, there were apparent differences in the impact of individual types of NPs on tested characteristics and function properties of MSCs. The results showed that individual types of NPs influence the activity of MSCs, and thus the use of metal NPs during tissue regeneration and in combination with stem cell therapy should be well considered.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA21-17720S" target="_blank" >GA21-17720S: The impact of metal nanoparticles on properties and functions of stem cells: an in vitro and in vivo study</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology in Vitro
ISSN
0887-2333
e-ISSN
1879-3177
Volume of the periodical
87
Issue of the periodical within the volume
mar
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
105536
UT code for WoS article
000910075000001
EID of the result in the Scopus database
2-s2.0-85144298955