The Impact of Morphine on the Characteristics and Function Properties of Human Mesenchymal Stem Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00492617" target="_blank" >RIV/67985823:_____/18:00492617 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/18:00492617 RIV/00216208:11310/18:10377681
Result on the web
<a href="http://dx.doi.org/10.1007/s12015-018-9843-8" target="_blank" >http://dx.doi.org/10.1007/s12015-018-9843-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12015-018-9843-8" target="_blank" >10.1007/s12015-018-9843-8</a>
Alternative languages
Result language
angličtina
Original language name
The Impact of Morphine on the Characteristics and Function Properties of Human Mesenchymal Stem Cells
Original language description
Morphine is an analgesic drug therapeutically administered to relieve pain. However, this drug has numerous side effects, which include impaired healing and regeneration after injuries or tissue damages. It suggests negative effects of morphine on stem cells which are responsible for tissue regeneration. Therefore, we studied the impact of morphine on the properties and functional characteristics of human bone marrow-derived mesenchymal stem cells (MSCs). The presence of -, - and -opioid receptors (OR) in untreated MSCs, and the enhanced expression of OR in MSCs pretreated with proinflammatory cytokines, was demonstrated using immunoblotting and by flow cytometry. Morphine modified in a dose-dependent manner the MSC phenotype, inhibited MSC proliferation and altered the ability of MSCs to differentiate into adipocytes or osteoblasts. Furthermore, morphine rather enhanced the expression of genes for various immunoregulatory molecules in activated MSCs, but significantly inhibited the production of the vascular endothelial growth factor, hepatocyte growth factor or leukemia inhibitory factor. All of these observations are underlying the selective impact of morphine on stem cells, and offer an explanation for the mechanisms of the negative effects of opioid drugs on stem cells and regenerative processes after morphine administration or in opioid addicts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cell Reviews and Reports
ISSN
1550-8943
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
801-811
UT code for WoS article
000449471900005
EID of the result in the Scopus database
2-s2.0-85052649219