Impaired Immunomodulatory Properties of the Retina from the Inflammatory Environment of the Damaged Eye

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00581917" target="_blank" >RIV/68378041:_____/23:00581917 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/23:10474052

Result on the web

<a href="https://link.springer.com/article/10.1007/s10753-023-01880-9" target="_blank" >https://link.springer.com/article/10.1007/s10753-023-01880-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10753-023-01880-9" target="_blank" >10.1007/s10753-023-01880-9</a>

Result language

angličtina

Original language name

Impaired Immunomodulatory Properties of the Retina from the Inflammatory Environment of the Damaged Eye

Original language description

The retina represents a highly specialized structure with the primary function to capture a light signal and to convert it into electrical impulses. Any damage or disease of the retina can cause visual impairment. Since retinal degenerative diseases are generally associated with immune cell infiltration, a local inflammatory reaction, and cytokine burn, there is a need for mechanisms to prevent the retina from damage by a deleterious immune reaction. In this study, we show that mouse retinal explants co-cultivated with stimulated spleen cells, inhibit in a dose-dependent manner the activation of T cells, and suppress the production of cytokines interleukin-2, interleukin-10, and interferon-?. The immunoregulatory properties of the retina were mainly mediated by a paracrine effect since retinal explants, separated by a semipermeable membrane, or supernatants obtained after the cultivation of retinal explants, inhibited the reactivity of immune cells. A model of retinal damage was established by the application of sodium iodate which selectively destroys photoreceptors, as it was demonstrated by a decrease in the number of rhodopsin-positive cells. This process was accompanied by increased infiltration of the retina with cells of the immune system and by a local inflammatory reaction. The pharmacologically damaged retina had significantly decreased the ability to inhibit T cell activation and production of cytokines by immune cells. Overall, the results showed that the retina possesses immunoregulatory properties and inhibits the activation and functions of T cells. However, the immunomodulatory properties of the retina are decreased if the retina is damaged.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Inflammation

ISSN

0360-3997

e-ISSN

1573-2576

Volume of the periodical

46

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

2320-2331

UT code for WoS article

001049086400001

EID of the result in the Scopus database

2-s2.0-85168105687