mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00585864" target="_blank" >RIV/68378041:_____/24:00585864 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/24:10480811
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fncel.2024.1298182/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fncel.2024.1298182/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fncel.2024.1298182" target="_blank" >10.3389/fncel.2024.1298182</a>
Alternative languages
Result language
angličtina
Original language name
mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells
Original language description
Neural stem cells (NSCs) are essential for both embryonic development and adult neurogenesis, and their dysregulation causes a number of neurodevelopmental disorders, such as epilepsy and autism spectrum disorders. NSC proliferation and differentiation in the developing brain is a complex process controlled by various intrinsic and extrinsic stimuli. The mammalian target of rapamycin (mTOR) regulates proliferation and differentiation, among other cellular functions, and disruption in the mTOR pathway can lead to severe nervous system development deficits. In this study, we investigated the effect of inhibition of the mTOR pathway by rapamycin (Rapa) on NSC proliferation and differentiation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cellular Neuroscience
ISSN
1662-5102
e-ISSN
1662-5102
Volume of the periodical
18
Issue of the periodical within the volume
May
Country of publishing house
CH - SWITZERLAND
Number of pages
14
Pages from-to
1298182
UT code for WoS article
001233414700001
EID of the result in the Scopus database
2-s2.0-85194840360