Mitochondrial DNA damage, repair, and replacement in cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00604253" target="_blank" >RIV/68378041:_____/25:00604253 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/25:00604253 RIV/00216208:11110/25:10486544 RIV/00216208:11140/25:10486544 RIV/00216208:11310/25:10486544
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S2405803324002127?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S2405803324002127?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trecan.2024.09.010" target="_blank" >10.1016/j.trecan.2024.09.010</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial DNA damage, repair, and replacement in cancer
Original language description
Mitochondria are vital organelles with their own DNA (mtDNA). mtDNA is circular and composed of heavy and light chains that are structurally more accessible than nuclear DNA (nDNA). While nDNA is typically diploid, the number of mtDNA copies per cell is higher and varies considerably during development and between tissues. Compared with nDNA, mtDNA is more prone to damage that is positively linked to many diseases, including cancer. Similar to nDNA, mtDNA undergoes repair processes, although these mechanisms are less well understood. In this review, we discuss the various forms of mtDNA damage and repair and their association with cancer initiation and progression. We also propose horizontal mitochondrial transfer as a novel mechanism for replacing damaged mtDNA.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Cancer
ISSN
2405-8033
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
62-73
UT code for WoS article
001401175500001
EID of the result in the Scopus database
2-s2.0-85207125126