Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00644120" target="_blank" >RIV/68378041:_____/25:00644120 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/25:00644120 RIV/00216208:11110/25:10505471 RIV/00216208:11130/25:10505471 RIV/00216208:11140/25:10505471 and 4 more
Result on the web
<a href="https://link.springer.com/article/10.1186/s10020-025-01400-5" target="_blank" >https://link.springer.com/article/10.1186/s10020-025-01400-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s10020-025-01400-5" target="_blank" >10.1186/s10020-025-01400-5</a>
Alternative languages
Result language
angličtina
Original language name
Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer
Original language description
BackgroundWhile nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA).MethodsThis study investigates mtDNA changes in CC, focusing on mitochondrial DNA copy number (mtDNA-CN) variations, mtDNA damage, and the expression and mutation status of DNA repair genes. Three cohorts were analyzed: healthy controls, colon adenoma patients, and CC patients, divided into a pilot and a validation set.ResultsOur findings revealed that mtDNA-CN was elevated in colon adenomas compared to adenoma-adjacent mucosa (FDR = 0.04), healthy mucosa (FDR = 0.005), and tumor-adjacent mucosa (FDR = 0.005). Moreover, mtDNA-CN was elevated in adenoma-adjacent mucosa compared to healthy mucosa (FDR = 0.04). MtDNA damage was greater in tumor-adjacent mucosa compared to tumor tissue in both the pilot and validation sets (FDR = 0.031 and FDR = 2.06e-05, respectively). Additionally, we identified novel DNA repair genes associated with mtDNA damage, predominantly upregulated in adenoma and tumor tissues compared to healthy colon tissues.ConclusionsTo conclude, this study highlights the importance of mtDNA alterations in CC development and identifies potential mtDNA biomarkers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Medicine
ISSN
1076-1551
e-ISSN
1528-3658
Volume of the periodical
31
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
341
UT code for WoS article
001650875500001
EID of the result in the Scopus database
2-s2.0-105026406251