Functional mitochondrial respiration is essential for glioblastoma tumour growth

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00637936" target="_blank" >RIV/68378041:_____/25:00637936 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/25:00637936 RIV/68378050:_____/25:00637936 RIV/00216208:11110/25:10497830 RIV/00216208:11130/25:10497830 and 2 more
Result on the web
<a href="https://www.nature.com/articles/s41388-025-03429-6" target="_blank" >https://www.nature.com/articles/s41388-025-03429-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41388-025-03429-6" target="_blank" >10.1038/s41388-025-03429-6</a>

Result language
angličtina
Original language name
Functional mitochondrial respiration is essential for glioblastoma tumour growth
Original language description
Horizontal transfer of mitochondria from the tumour microenvironment to cancer cells to support proliferation and enhance tumour progression has been shown for various types of cancer in recent years. Glioblastoma, the most aggressive adult brain tumour, has proven to be no exception when it comes to dynamic intercellular mitochondrial movement, as shown in this study using an orthotopic tumour model of respiration-deficient glioblastoma cells. Although confirmed mitochondrial transfer was shown to facilitate tumour progression in glioblastoma, we decided to investigate whether the related electron transport chain recovery is necessary for tumour formation in the brain. Based on experiments using time-resolved analysis of tumour formation by glioblastoma cells depleted of their mitochondrial DNA, we conclude that functional mitochondrial respiration is essential for glioblastoma growth in vivo, because it is needed to support coenzyme Q redox cycling for de novo pyrimidine biosynthesis controlled by respiration-linked dihydroorotate dehydrogenase enzyme activity. We also demonstrate here that astrocytes are key mitochondrial donors in this model.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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