Letter to the Editor Rebuttal to Qi et al. (2025): Alpha 9 integrin in spinal cord repair: a critical appraisal of mechanisms, circuitry, and translational potential

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00644520" target="_blank" >RIV/68378041:_____/25:00644520 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1186/s40478-025-02186-7" target="_blank" >https://link.springer.com/article/10.1186/s40478-025-02186-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s40478-025-02186-7" target="_blank" >10.1186/s40478-025-02186-7</a>

Result language
angličtina
Original language name
Letter to the Editor Rebuttal to Qi et al. (2025): Alpha 9 integrin in spinal cord repair: a critical appraisal of mechanisms, circuitry, and translational potential
Original language description
In response to the commentary by Qi et al. (2025) on our recent study of alpha 9 integrin in spinal cord repair, we provide clarifications on several factual and interpretative points. The alpha 9 integrin binding site resides within the third fibronectin type III-like repeat of tenascin-C, which is not alternatively spliced, ensuring consistent ligand engagement. Multiple studies, including those by Dobbertin et al., Cimpean et al., and Tan et al. support the pro-regenerative role of alpha 9 integrin and its ability to overcome CSPG-mediated inhibition through Src and FAK signalling. We further note that long-term studies are indeed warranted and have facilitated such research by depositing all constructs on Addgene. Contrary to the commentarys claim, our study employed a spinal cord injury model, not a dorsal root crush, and histological data confirm the presence of a fibrotic scar. No evidence of neuropathic pain was observed at 12 weeks, indicating functional safety within the study timeframe. Together, these clarifications reaffirm that alpha 9 integrin signalling directly promotes axon regeneration and that future work using temporally controlled systems will build on these findings.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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