Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of .alfa.5.beta.1 integrin expression.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F00%3A23010241" target="_blank" >RIV/68378050:_____/00:23010241 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of .alfa.5.beta.1 integrin expression.

Original language description

The PAX6 gene, a key regulator of eye development, produces two major proteins that differ in paired domain structure: PAX6 and PAX6(5a). It is known that an increase in the PAX6(5a) to PAX6 ratio leads to multiple ocular defects in humans. Here, transgenic mice were created that overexpress human PAX6(5a) in the lens.These transgenic mice are good models to study a type of human cataract and for identifying batteries of genes that are directly of indirectly regulated by both forms of Pax-6.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cell Science

ISSN

0021-9533

e-ISSN

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Volume of the periodical

113

Issue of the periodical within the volume

18

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

3173-3185

UT code for WoS article

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EID of the result in the Scopus database

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