Genetic interaction between Pax6 and ?-catenin in the developing retinal pigment epithelium

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455800" target="_blank" >RIV/68378050:_____/15:00455800 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00427-015-0493-4" target="_blank" >http://dx.doi.org/10.1007/s00427-015-0493-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00427-015-0493-4" target="_blank" >10.1007/s00427-015-0493-4</a>

Result language

angličtina

Original language name

Genetic interaction between Pax6 and ?-catenin in the developing retinal pigment epithelium

Original language description

Wnt/beta-catenin signaling plays an essential role in the retinal pigment epithelium (RPE) determination. Since activity of Pax6 (together with Pax2) is also required for the RPE determination, we investigated a possible genetic interaction between Pax6and Wnt/beta-catenin signaling pathway by analyzing Pax6, beta-catenin, and Pax6/beta-catenin conditional knockout mice. Although Pax6 inactivation alone had no impact on initial specification determined by the expression of Mitf and Otx2, melanin pigmentation was reduced in the RPE. This suggests that along with Mitf and Otx2, Pax6 is required for the full differentiation of RPE. Reporter gene assays in vitro suggest that hypopigmentation is at least in part due to the direct regulation of genes encoding enzymes involved in melanin synthesis by Pax6, Mitf, and beta-catenin. The RPE of a beta-catenin/Pax6 double mutant was differentiated into the neural retina; however, the tissue was thinner than that of the conditional beta-catenin mu

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Development Genes and Evolution

ISSN

0949-944X

e-ISSN

—

Volume of the periodical

225

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

121-128

UT code for WoS article

000351605300006

EID of the result in the Scopus database

—