TRAIL/APO2L inhibits myelodysplasia and myeloid leukemia progenitor growth while it does not affect normal progenitors in vitro and normal CD3+ cell repopulation in NOD/SCID mice.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F01%3A23010499" target="_blank" >RIV/68378050:_____/01:23010499 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
TRAIL/APO2L inhibits myelodysplasia and myeloid leukemia progenitor growth while it does not affect normal progenitors in vitro and normal CD3+ cell repopulation in NOD/SCID mice.
Original language description
Susceptibility of primary malignant and normal hematopoietic progenitors to TRAIL-induced apoptosis was studied by clonogenic assays and by their repopulating potential after transplantation into NOD/SCID mice. In E. coli produced extacellular part of human TRAIL (Aas 95-281) significantly reduced the number of myeloid colonies (CFU-GM) and clusters from patients with AML, CML, and MDS szndromes bud did not inhibited in vitro and in vivo growth of normal hematopoietic progenitors and stem cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA5052001" target="_blank" >IAA5052001: Characterization and potential therapeutical use of TRAIL-mediated apoptosis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood
ISSN
0006-4971
e-ISSN
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Volume of the periodical
98
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
1
Pages from-to
3043
UT code for WoS article
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EID of the result in the Scopus database
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