TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F02%3A23010500" target="_blank" >RIV/68378050:_____/02:23010500 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/02:00000025

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors.

Original language description

Susceptibility of primary malignant and normal hematopoietic progenitors to TRAIL-induced apoptosis was studied by clonogenic assays and by their repopulating potential after transplantation into NOD/SCID mice. In E. coli produced extacellular part of human TRAIL (Aas 95-281) significantly reduced the number of myeloid colonies (CFU-GM) and clusters from patients with AML, CML, and MDS szndromes bud did not inhibited in vitro and in vivo growth of normal hematopoietic progenitors and stem cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia

ISSN

0887-6924

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

67-73

UT code for WoS article

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EID of the result in the Scopus database

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