Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F03%3A23033033" target="_blank" >RIV/68378050:_____/03:23033033 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Crystallographic study of an anti=carbonic anhydrase IX monoclonal antibody M75.
Original language description
Carbonic anhydrase IX (CA IX) is a cell surface protein, strongly associated with certain types of human carcinomas. Structural study of a CA IX-binding monoclonal antibody (mAb) M75, complexed with its epitope peptide may contribute toward elucidation of the role of CA IX. Monoclonal antibody M75 was obtained and proved to react excellently with native and denaturated CA IX. Using synthetic oligopeptides, the epitope of mAb M75 was localized in the proteoglycan domain of CA IX, in the region of a tandem repeat and identified as amino acids PGEEDLP. The Fab fragment was obtained by papain cleavage. We obtained crystals of free Fab M75 and Fab M75 complexed with two different epitope peptides. The data set for Fab M75 was collected and the structure solving is underway.
Czech name
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Czech description
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Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Material Structure in Chemistry, Biology, Physics and Technology.
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
70
Publisher name
Czech and Slovak Crystallographic Association
Place of publication
Praha, Česká republika
Event location
Nové Hrady [CZ]
Event date
Mar 13, 2003
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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