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Structural basis of HIV-1 and HIV-2 protease inhibition bya monoclonal antibody.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F03%3A23033037" target="_blank" >RIV/68378050:_____/03:23033037 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structural basis of HIV-1 and HIV-2 protease inhibition bya monoclonal antibody.

  • Original language description

    The murine monoclonal antibody 1696, produced by immunisation with the HIV-1 protease,inhibits the catalytic activity of the enzyme of both the HIV-1 and HIV-2 isolates, with inhibitionconstants in the low nanomolar range. This antibody cross-reacts withpeptides that include theN-terminus of the enzyme (residues 1-7), a region which is highly conserved in sequence amongdifferent viral strains and which, furthermore, is crucial for homodimerization to the activeenzymatic form.<?xml:namespace prefix = ons = 'urn:schemas-microsoft-com:office:office' />We report here two crystal structures of a recombinant single-chain Fv fragment of mAb 1696,expressed in E. coli, as a complex with a cross-reactive peptides from the HIV-1 PR and theHIV-2 PR at 2.7 ? resolution and 1.9 ? resolution respectively. On the basis of the interactionsseen in the complex three-dimensional structures, the cross-reactivity between mAb 1696 withthe HIV-1 and HIV-2 protease and their N-terminal peptides can be explai

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GV203%2F98%2FK023" target="_blank" >GV203/98/K023: Protein crystallography analyses of liganded proteinase of human immunodeficiency virus ( HIV ) for design of novel anti - AIDS compounds</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Material Structure in Chemistry, Biology, Physics and Technology.

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

    70

  • Publisher name

    Czech and Slovak Crystallographic Association

  • Place of publication

    Praha, Česká republika

  • Event location

    Nové Hrady [CZ]

  • Event date

    Mar 13, 2003

  • Type of event by nationality

    CST - Celostátní akce

  • UT code for WoS article