The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F04%3A00108993" target="_blank" >RIV/68378050:_____/04:00108993 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours
Original language description
Depletion of NK1.1+ cells by repeated i.p. injections of PK136 antibody significantly enhanced growth of MHC class I+ tumours in syngeneic mice. Depletion starting before tumour transplantation substantially accelerated tumour growth; depletion startingon day 7 or 14 after tumour transplantation was without any effect. These results indicate that the NK1.1+ cells play an important inhibitory role during the early phase of the growth of some MHC class I+ tumours. Since the relevant target for NK cells is a "missing self" signal, absence of the MHC class I molecules, the NK cells cannot be expected to directly inhibit the growth of the MHC class I+ tumours. The results indicate that the effects of non-NK cells or indirect effects mediated by NK cell interactions and release of cytokines were responsible for the results
Czech name
Úloha buněk NK1.1+ v ochraně proti MHC I+ nádorům vyvolaným HPV16
Czech description
Deplece buněk NK1.1+ opakovanými i.p. injekcemi protilátky PK136 výrazně posílilo růst MHC I+ nádorů v syngenních myších. Deplece započatá před transplantací nádoru podstatně urychlila jejich růst; deplece započatá 7. či 14. den po transplantaci nádoru neměla žádný účinek. Z těchto výsledků vyplývá, že buňky NK1.1+ hrají důležitou inhibiční úlohu během časné fáze růstu některých MHC I+ nádorů
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia Biologica
ISSN
0015-5500
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
3
Pages from-to
200-202
UT code for WoS article
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EID of the result in the Scopus database
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