NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00355110" target="_blank" >RIV/68378050:_____/11:00355110 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

Original language description

In vivo depletion of CD8+ cells resulted in complete elimination of protective effects after immunization with TC-1 cells (MHC class I+) against the TC-1 tumour challenge. After immunization with TC-1/A9 or MK16 tumour cells (MHC class I-deficient) a remarkable dependence on the presence of NK1.1+ cells was observed, Cytotoxic activity induced by TC-1 cell immunization was abrogated in CD8+ cell-depleted mice and the mice showed similar percentage of IFNgamma-producing cells in CD8+, CD4+ and NK1.1+ subpopulations.. After MK16 or TC-1/A9 cell immunization, NK1.1+ displayed significant reduction of cytotoxicity. The highest proportion of IFNgamma-producing cells was concentrated into the NK1.1+ cells..

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/IAA500520807" target="_blank" >IAA500520807: Mechanisms of protective immunity against tumours with different expression of immunodulatory molecules</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

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UT code for WoS article

000286303800038

EID of the result in the Scopus database

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