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Expression pattern of adaptor protein PAG: correlation between secondary lymphatic follicle and histogenetically related malignant lymphomas

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00021323" target="_blank" >RIV/68378050:_____/05:00021323 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/05:00003045

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression pattern of adaptor protein PAG: correlation between secondary lymphatic follicle and histogenetically related malignant lymphomas

  • Original language description

    Transmembrane adaptor protein PAG, also known as Csk-binding protein (Cbp), which binds and activates the cytoplasmic tyrosine kinase Csk, the major negative regulator of Src-family kinases, was found to be expressed in germinal centers of lymphoid follicles as well as in follicular, but not mantle cell lymphomas. Expression of PAG may reflect its role in regulation of proliferation and differentiation of germinal center B-cells. From the routine histopathology point of view, PAG might be a new positivemarker of follicular lymphoma and a negative marker of mantle cell lymphoma.

  • Czech name

    Exprese adaptorového proteinu PAG: korelace mezi sekundárním lymfatickým folikulem a histogeneticky příbuznými maligními lymfomy

  • Czech description

    Bylo zjištěno, že transmembránový adaptorový protein PAG, který váže a aktivuje cytoplasmatickou kinasu Csk, je exprimován v zárodečných centrech lymfoidních folikulů a také ve folikulárních, avšak nikoli plášťových lymfomech. Exprese PAG může odrážet jeho roli v regulaci proliferace a diferenciace B buněk v zárodečném centru. PAG může být novým užitečným pozitivním markerem folikulárních lymfomů a negativním markerem plášťových lymfomů pro klinickou histopatologii.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Immunology Letters

  • ISSN

    0165-2478

  • e-ISSN

  • Volume of the periodical

    100

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    4

  • Pages from-to

    94-97

  • UT code for WoS article

  • EID of the result in the Scopus database