Pax genes in eye development and evolution
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00022522" target="_blank" >RIV/68378050:_____/05:00022522 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pax genes in eye development and evolution
Original language description
Animal eyes with widely different anatomical designs have long been thought to arise independently, multiple times during evolution. This view was challenged about a decade ago by the landmark discoveries that Pax6, a highly conserved transcription factor, plays a key role in eye morphogenesis in both flies and mammals. Since then, more evidence has emerged in favour of the redeployment of Pax6 and some other developmental control genes within the genetic program underlying eye formation throughout theanimal kingdom. Recent work has indicated that other members of the Pax gene family play a pivotal role in eye morphogenesis. The Eye gone gene regulates eye growth in Drosophila, whereas the PaxB gene is implicated in visual system development in jellyfish, the most basal organism possessing eyes.
Czech name
Geny Pax ve vývoji oka a v evoluci
Czech description
Oči zvířat se liší z anatomického hlediska. Proto se předpokládalo, že vznikly nezávisle několikrát v průběhu evoluce. Objev genu Pax6 zhruba před deseti lety ale všechny tyto argumenty zpochybnil. Od té doby se objevilo více důkazů pro opakované použitígenu Pax6 a některých dalších regulátorů používaných pro genetický program vývoje oka. Nedávný výzkum ukázal, že i některé další geny rodiny Pax hrají klíčovou roli v morfogenezi oka.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Genetics & Development
ISSN
0959-437X
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
430-438
UT code for WoS article
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EID of the result in the Scopus database
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