The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta2-microglobulin-free HLA-G molecules
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00023580" target="_blank" >RIV/68378050:_____/05:00023580 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta2-microglobulin-free HLA-G molecules
Original language description
In the present study, we demonstrate that HLA-G must associate with beta(2)m for its interaction with CD85J/leukocyte Ig-like receptor-1 (LIR-1). Although HLA-G free H chain complexes are expressed on the surface, they are not recognized and possibly interfere with CD85J/LIR-1 and HLA-G interaction. The formation of these complexes on the cell surface might represent a novel mechanism developed specifically by the HLA-G protein aimed to control the efficiency of the CD85J/LIR-1-mediated inhibition. We also show that endogenous HLA-G complexes are expressed on the cell surface. These findings provide novel insights into the delicate interaction between extravillous cytotrophoblast cells and NK cells in the decidua.
Czech name
CD85/leukocytární inhibiční receptor 1 rozlišuje mezi konformovanými molekulami HLA-G a molekulami HLA-G neobsahujícími beta2-mikroglobulin
Czech description
V této studii je demonstrováno, že molekuly HLA-G musí asociovat s beta-2-mikroglobulinem, aby byly schopny interagovat s inhibičním receptorem CD85J (LIR). Tvorba těchto komplexů na buněčném povrchu může představovat nový mechanismus kontroly inhibice imunocytů (NK buněk) zprostředkované receptorem LIR-1 při kontaktech mezi buňkami trofoblastu a deciduálními NK buňkami.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Immunology
ISSN
0022-1767
e-ISSN
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Volume of the periodical
175
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
4866-4874
UT code for WoS article
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EID of the result in the Scopus database
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