Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00025555" target="_blank" >RIV/68378050:_____/05:00025555 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription
Original language description
It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function.
Czech name
Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem
Czech description
Předpokládá se, že prozánětlivá odpověď a hyperaktivita HPA osy je zahrnuta v patogenesi deprese. Již dříve jsme zjistili, že antidepresiva inhibují v in vitro podmínkách funkci glukokortikoidního receptoru (GR). Zkoumali jsme vliv LPS na imipramin- nebofluoxetinem indukovanou inhibici GR ovlivněné genové transkripce ve fibroblastech. Výsledky naznačují, že prozánětlivá agens usnadňují antidepresivy indukovanou inhibici funkce GR.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacological Reports
ISSN
1734-1140
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
4
Country of publishing house
PL - POLAND
Number of pages
5
Pages from-to
540-544
UT code for WoS article
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EID of the result in the Scopus database
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