Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00092897" target="_blank" >RIV/68378050:_____/07:00092897 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours

Original language description

Loss or downregulation of MHC class I molecules on tumour cells is a common mechanism by which tumours can escape from T-cell mediated immune responses. In this study we have investigated the immunologic crossreactivity between murine tumour cell lines expressing human papilloma virus (HPV) 16-derived E6/E7 oncoproteins with distinct surface expression of MHC class I molecules. Our data showed that immunization with MHC class I-deficient but not with MHC class I positive tumour cells inhibited the growth of MHC class I-deficient tumours. In vivo depletion studies revealed that the mechanisms underlying effective immune responses against MHC class I-negative tumours in animals immunized with MHC class I-deficient tumour cells involved natural killer cells. The presented findings are of particular clinical relevance in the sense of construction of vaccines directed against a broad spectrum of HPV-associated tumours.

Czech name

Imunizace MHC I negativními nádorovými buňkami, ale nikoliv pozitivními, asociovanými s HPV16 inhibovala růst MHC I negativních asociovaných s HPV16

Czech description

Byla studována křížová imunitní reakce mezi nádory exprimující stejné nádorové antigeny, ale s různou úrovní MHC molekul I. třídy. Výsledky ukázaly, že zatímco imunizace ozářenými MHC I-negativními buňkami vedla k inhibici růstu MHC pozitivních i negativních nádorů, imunizace MHC I-pozitivními buňkami inhibovala pouze růst MHC I-pozivních nádorů.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NR7807" target="_blank" >NR7807: Tumours of human papillomavirus origin with different expression of MHC class I molecules: theoretical principles of immunotherapy.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Oncology

ISSN

1019-6439

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

1011-1017

UT code for WoS article

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EID of the result in the Scopus database

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