Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00371265" target="_blank" >RIV/68378050:_____/11:00371265 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/bjc.2011.428" target="_blank" >http://dx.doi.org/10.1038/bjc.2011.428</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/bjc.2011.428" target="_blank" >10.1038/bjc.2011.428</a>
Alternative languages
Result language
angličtina
Original language name
Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
Original language description
We evaluated the anti-tumour effects of the DNA methyltransferase inhibitor 5-azacytidine (5AC) The 5AC therapy was combined with immunotherapy, using a murine model for HPV16-associated tumours. We have demonstrated 5AC additive effects against MHC class I-positive and -deficient tumours when combined with unmethylated CpG oligodeoxynucleotides (CpG ODN) or with IL-12-producing cellular vaccine. The efficacy of the combined chemoimmunotherapy against originally MHC class I-deficient tumours was partially dependent on the CD8+-mediated immune responses. Increased cell surface expression of MHC class I cell molecules, associated with upregulation of the antigen-presenting machinery-related genes, as well as of genes encoding selected components of the IFN? signalling pathway in tumours explanted from 5AC-treated animals, were observed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Cancer
ISSN
0007-0920
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1533-1541
UT code for WoS article
000296794200009
EID of the result in the Scopus database
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