CpG methylation controls reactivation of HIV from latency

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F09%3A00333948" target="_blank" >RIV/68378050:_____/09:00333948 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
CpG methylation controls reactivation of HIV from latency
Original language description
HIV-1 latency is the main obstacle to the eradication of the virus from infected patients. CpG methylation is known to contribute to transcriptional silencing in general, its role in HIV-1 latency, however, has not been clearly demonstrated and has neverbeen studied in HIV-1-infected patients. We found in an in vitro model and in HIV-1-infected patients that CpG methylation of the HIV-1 promoter is important for the maintenance but not for the establishment of HIV-1 latency. That tight control of HIV-1latency by CpG methylation could be a key barrier to purging the reservoir of latently infected cells in infected individuals. Our study shows that addition of some histone deacetylase and methyltransferase inhibitors (namely SAHA) reactivate latent HIVand could represent an important part of HAART protocols in the future.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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