Development of 5 ' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00471925" target="_blank" >RIV/68378050:_____/16:00471925 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/16:00472257 RIV/00216208:11110/16:10323674 RIV/00216208:11310/16:10323674 RIV/00216208:11120/16:43911073 and 2 more
Result on the web
<a href="http://dx.doi.org/10.1186/s13148-016-0185-6" target="_blank" >http://dx.doi.org/10.1186/s13148-016-0185-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13148-016-0185-6" target="_blank" >10.1186/s13148-016-0185-6</a>
Alternative languages
Result language
angličtina
Original language name
Development of 5 ' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals
Original language description
Background: Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (5' LTR) restricts HIV-1 reactivation and, together with chromatin conformation, represents an important mechanism of HIV-1 latency maintenance. Here, we explored the new issue of temporal development of DNA methylation in latent HIV-1 5' LTR.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP304%2F12%2F1736" target="_blank" >GAP304/12/1736: Development of CpG methylation of HIV-1 promoter and its stabilizing effect on the latent provirus reservoir: longitudinal study in patients</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Epigenetics
ISSN
1868-7083
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
zima
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
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UT code for WoS article
000370484600001
EID of the result in the Scopus database
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