Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F10%3A00346779" target="_blank" >RIV/68378050:_____/10:00346779 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells

Original language description

Glial tumors exhibit a high morbidity and mortality because of their invasive nature. Matrix metalloproteinase 19 (MMP19) is a secreted protease that together with epilysin (MMP28) forms a structural subgroup of MMPs. In contrast, MMP19 was detected in normal brain samples only in endothelial cells but was found at high levels in astrocytomas. MMP19 was upregulated in GB cells after exposure to proinflammatory cytokines. MMP19-silenced cells migrated more slowly through laminin-, basal lamina-, and brevican-coated membranes than controls. MMP19-silenced GB cells also migrated into brain tissue slices compared with control cells. Brevican, a brain-specific proteoglycan and major component of brain extracellular matrix, was degraded by recombinant humanMMP19. MMP19 is highly expressed in proliferating astrocytoma/glioma cells and its expression may facilitate their invasion through brain extracellular matrix

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuropathology and Experimental Neurology

ISSN

0022-3069

e-ISSN

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Volume of the periodical

69

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

000275418600001

EID of the result in the Scopus database

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