BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00371711" target="_blank" >RIV/68378050:_____/11:00371711 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/1476-4598-10-118" target="_blank" >http://dx.doi.org/10.1186/1476-4598-10-118</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1476-4598-10-118" target="_blank" >10.1186/1476-4598-10-118</a>
Alternative languages
Result language
angličtina
Original language name
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
Original language description
Colorectal cancer is a common disease that involves genetic alterations, such as inactivation of tumour suppressor genes and activation of oncogenes such as or BRAF. The aim of this study is to dissect cell migration and invasion pathways that are utilised by BRAFV600E and mutated RAS oncoproteins. Colon adenocarcinoma cells with endogenous as well as ectopically expressed or silenced oncogenic mutations of BRAFV600E, KRASG12V and HRASG12V were employed. BRAFV600E significantly induces cell migration and invasion of colon cancer cells partly via activation of RhoA GTPase. KRASG12V enhances the ability of colon adenocarcinoma cells Caco-2 to migrate and invade through filopodia formation. Increased cell migration and invasion, mediated by Rac1 and mesenchymal morphology were the main characteristics rendered by HRASG12V in Caco-2 cells. RAS oncogenes can also cooperate with the TGFbeta-1 pathway in cellular transformation.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Cancer
ISSN
1476-4598
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
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Country of publishing house
GB - UNITED KINGDOM
Number of pages
21
Pages from-to
"e118"
UT code for WoS article
000295831300001
EID of the result in the Scopus database
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