Genetic control of resistance to Trypanosoma brucei brucei infection in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00363620" target="_blank" >RIV/68378050:_____/11:00363620 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pntd.0001173" target="_blank" >http://dx.doi.org/10.1371/journal.pntd.0001173</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pntd.0001173" target="_blank" >10.1371/journal.pntd.0001173</a>
Alternative languages
Result language
angličtina
Original language name
Genetic control of resistance to Trypanosoma brucei brucei infection in mice
Original language description
Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal speciesincluding livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1?4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA500520606" target="_blank" >IAA500520606: Mapping and Identification of Genes that Control Proliferation of Activated Lymphocytes and Study of their Relationship to Disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Neglected Tropical Diseases
ISSN
1935-2735
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"e1173"
UT code for WoS article
000292139600018
EID of the result in the Scopus database
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