SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00370084" target="_blank" >RIV/68378050:_____/11:00370084 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1128/MCB.05817-11" target="_blank" >http://dx.doi.org/10.1128/MCB.05817-11</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/MCB.05817-11" target="_blank" >10.1128/MCB.05817-11</a>
Alternative languages
Result language
angličtina
Original language name
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling
Original language description
The discovery of a new palmitoylated transmembrane adaptor protein, termed SCIMP, is described. SCIMP is expressed in B cells and other professional APCs and is localized in the immunological synapse due to its association with tetraspanin-enriched microdomains. In B cells, it is constitutively associated with Lyn kinase and becomes tyrosine phosphorylated after major histocompatibility complex type II (MHC-II) stimulation. When phosphorylated, SCIMP binds to the SLP65 adaptor protein and also to the inhibitory kinase Csk. While the association with SLP65 initiates the downstream signaling cascades, Csk binding functions as a negative regulatory loop. The results suggest that SCIMP is involved in signal transduction after MHC-II stimulation and therefore serves as a regulator of antigen presentation and other APC functions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Biology
ISSN
0270-7306
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
22
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
4550-4562
UT code for WoS article
000296704900013
EID of the result in the Scopus database
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