Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00378912" target="_blank" >RIV/68378050:_____/11:00378912 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Targeting beta III-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics
Original language description
Glioblastoma multiforme (GBM) is the most common, aggressive, and chemorefractory brain tumor in human adults. Notwithstanding significant discoveries in the elucidation of signaling pathways and genetics of GBM during the past 20 years there has been nobreakthrough in the pharmacological treatment of this high-grade malignancy. We have previously demonstrated increased expression of ?III-tubulin in GBM asserting a link between aberrant expression of ?III-tubulin and a disruption of microtubule dynamics associated either with malignant tumor development de novo, or with malignant transformation of a low-grade glioma into GBM. This article reviews ?III-tubulin as a promising target in the experimental treatment of GBM and examines the potential use ofepothilones, a new family of anticancer agents shown to be active in ?III-tubulin-expressing tumor cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP302%2F10%2F1759" target="_blank" >GAP302/10/1759: Function-structure relationships between transmembrane adaptor-based signalosomes in mast cells</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anti-Cancer Agents in Medicinal Chemistry
ISSN
1871-5206
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
8
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
719-728
UT code for WoS article
000298057800005
EID of the result in the Scopus database
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