LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00441201" target="_blank" >RIV/68378050:_____/11:00441201 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES
Original language description
The laboratory mouse is the most common mammalian model organism for research of the human body functions and disorders. For experimental purposes mice selected from inbred strains, developed by many generations of brother-sister crosses, are usually used. Individual mice of a given inbred strain are therefore considered genetically identical. However, our preliminary observations suggest that for a number of phenotypic traits mice originating from the same litter are significantly more similar than mice coming from different litters of the same inbred strain. We estimated the size of this litter effect for a number of traits in several phenotypic studies. By means of simulation we showed that ignoring the litter effect may result in several fold higher false positive rate and severe underestimation of minimal sample size.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
BIOINFORMATICS 2011, Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
ISBN
978-989-8425-36-2
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
238-243
Publisher name
SCITEPRESS, AV D MANUELL, 27A 2 ESQ, SETUBAL, 2910-595, PORTUGAL
Place of publication
SETUBAL, PORTUGAL
Event location
Setubal
Event date
Jan 26, 2011
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000308455800038

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