Healthy first-degree relatives of patients with type 1 dabetes exhibit significant differences in basal gene expression pattern of immunocompetent cells compared to controls: expression pattern as predeterminant of autoimmune diabetes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00376079" target="_blank" >RIV/68378050:_____/12:00376079 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1365-3083.2011.02637.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-3083.2011.02637.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1365-3083.2011.02637.x" target="_blank" >10.1111/j.1365-3083.2011.02637.x</a>

Result language
angličtina
Original language name
Healthy first-degree relatives of patients with type 1 dabetes exhibit significant differences in basal gene expression pattern of immunocompetent cells compared to controls: expression pattern as predeterminant of autoimmune diabetes
Original language description
Expression features of genetic landscape which predispose an individual to the type 1 diabetes are poorly understood. We addressed this question by comparing gene expression profile of freshly isolated peripheral blood mononuclear cells isolated from either patients with type 1 diabetes (T1D), or their first-degree relatives or healthy controls. Our aim was to establish whether a distinct type of prodiabetogenic gene expression pattern in the group of relatives of patients with T1D could be identified.Whole-genome expression profile of nine patients with T1D, their ten first-degree relatives and ten healthy controls was analysed using the human high-density expression microarray chip. Functional aspects of candidate genes were assessed using the MetaCore software. The highest number of differentially expressed genes (547) was found between the autoantibody-negative healthy relatives and the healthy controls. Some of them represent genes critically involved in the regulation of innate
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/2B08066" target="_blank" >2B08066: Novel treatment of genetically determined metabolic disease, type 1 diabetes, using an immunotherapeutical approach.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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