Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00382929" target="_blank" >RIV/68378050:_____/12:00382929 - isvavai.cz</a>

Alternative codes found

RIV/68081766:_____/12:00382929

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pgen.1003044" target="_blank" >http://dx.doi.org/10.1371/journal.pgen.1003044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pgen.1003044" target="_blank" >10.1371/journal.pgen.1003044</a>

Result language

angličtina

Original language name

Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility

Original language description

The Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has been characterized at the gene levelin mammals. The Hybrid sterility 1 gene (Hst1) participates in the arrest of meiosis in F(1) males of certain strains from two Mus musculus subspecies, e.g., PWD from M. m. musculus and C57BL/6J (henceforth B6) from M. m. domesticus. Hst1 has been identified as a meiotic PR-domain gene (Prdm9) encoding histone 3 methyltransferase in the male offspring of PWD females and B6 males, (PWDB6)F(1). To characterize the incompatibilities underlying hybrid sterility, we phenotyped reproductive and meiotic markers in males with altered copy numbers of Prdm9. A partial rescue of fertility was observed upon removal of the B6 allele of Prdm9 from the azoospermic (PWDB6)F(1) hybrids, whereas removing one of the two Prdm9 copies in PWD or B6 backgrou

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS Genetics

ISSN

1553-7404

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

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UT code for WoS article

000311891600032

EID of the result in the Scopus database

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