The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts''
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00387633" target="_blank" >RIV/68378050:_____/12:00387633 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0036330" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0036330</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0036330" target="_blank" >10.1371/journal.pone.0036330</a>
Alternative languages
Result language
angličtina
Original language name
The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts''
Original language description
The importance of membrane compartmentalization into specific membrane microdomains has been shown in many biological processes such as immunoreceptor signaling, membrane trafficking, pathogen infection, and tumor progression. Microdomains like lipid rafts, caveolae and tetraspanin enriched microdomains are relatively resistant to solubilization by some detergents. Large detergent-resistant membrane fragments (DRMs) resulting from such membrane solubilization can be conveniently isolated by density gradient ultracentrifugation or gel filtration. Recently, we described a novel type of raft-like membrane microdomains producing, upon detergent Brij98 solubilization, ?heavy DRMs and containing a number of functionally relevant proteins. Transmembrane adaptor protein LAX is a typical ?heavy raft protein. The present study was designed to identify the molecular determinants targeting LAX-derived constructs to heavy rafts. We identified the transmembrane domain of LAX as a first motif targeti
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000305342300011
EID of the result in the Scopus database
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