A new type of membrane raft-like microdomains and their possible involvement in TCR signaling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F10%3A00346793" target="_blank" >RIV/61388971:_____/10:00346793 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/10:00346793
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A new type of membrane raft-like microdomains and their possible involvement in TCR signaling
Original language description
One of the key signaling molecules present in T cell detergent-resistant membrane domains (DRMs) derived from membrane rafts is the transmembrane adaptor protein LAT (linker for activation of T cells). In contrast to previous results, a recent study demonstrated that a LAT construct not present in the buoyant DRMs is fully able to support TCR signaling and development of T cells in vivo. This finding caused doubts about the real physiological role of rafts in TCR signaling. In this study, we demonstratethat these results can be explained by the existence of a novel type of membrane raft-like microdomains, containing a number of membrane molecules. At a moderate level of expression, LAT supported TCR signaling more efficiently than constructs targetedto the microdomains producing heavy DRMs or to nonraft membrane. We suggest that different types of membrane microdomains provide environments regulating the functional efficiencies of signaling molecules present therein.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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