Lck, membrane microdomains, and TCR triggering machinery: defining the new rules of engagement

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00381599" target="_blank" >RIV/68378050:_____/12:00381599 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3389/fimmu.2012.00155" target="_blank" >http://dx.doi.org/10.3389/fimmu.2012.00155</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2012.00155" target="_blank" >10.3389/fimmu.2012.00155</a>

Result language

angličtina

Original language name

Lck, membrane microdomains, and TCR triggering machinery: defining the new rules of engagement

Original language description

In spite of a comprehensive understanding of the schematics of T cell receptor (TCR) signaling, the mechanisms regulating compartmentalization of signaling molecules, their transient interactions, and rearrangement of membrane structures initiated upon TCR engagement remain an outstanding problem. These gaps in our knowledge are exemplified by recent data demonstrating that TCR triggering is largely dependent on a preactivated pool of Lck concentrated in T cells in a specific type of membrane microdomains. Our current model posits that in resting T cells all critical components of TCR triggering machinery including TCR/CD3, Lck, Fyn, CD45, PAG, and LAT are associated with distinct types of lipid-based microdomains which represent the smallest structural and functional units of membrane confinement able to negatively control enzymatic activities and substrate availability that is required for the initiation of TCR signaling. In addition, the microdomains based segregation spatially limi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

June

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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