The roles of membrane microdomains (rafts) in T cell activation.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F03%3A23033075" target="_blank" >RIV/68378050:_____/03:23033075 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The roles of membrane microdomains (rafts) in T cell activation.
Original language description
The conference has dealt with multiple aspects of T cell immunity, the major topic was regulatory T cells. Detergent-resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essentialroles in T cell receptor (TCR) signaling. These 'membrane rafts' accumulate several cytoplasmic lipid-modified molecules, including Src-family kinases, coreceptors CD4 and CD8 and transmembrane adapters LAT and PAG/Cbp, essential for either initiation oramplification of the signaling process. T cell subpopulations may differ in their use of membrane rafts. Membrane rafts are involved in many other aspects of T cell biology, such as functioning of cytokine and chemokine receptors, adhesion molecules, antigen presentation, establishing cell polarity or interaction with pathogens. Many basic raft issues, such as composition, size and heterogeneity, under native conditions, as well as the dynamics of their interactions with TCRs and other
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/LN00A026" target="_blank" >LN00A026: Center of molecular and cellular immunology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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