Transmembrane adaptor proteins in the high-affinity IgE receptor signaling

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00399709" target="_blank" >RIV/68378050:_____/12:00399709 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3389/fimmu.2011.00095" target="_blank" >http://dx.doi.org/10.3389/fimmu.2011.00095</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2011.00095" target="_blank" >10.3389/fimmu.2011.00095</a>

Result language

angličtina

Original language name

Transmembrane adaptor proteins in the high-affinity IgE receptor signaling

Original language description

Aggregation of the high-affinity IgE receptor (Fc?RI) initiates a cascade of signaling events leading to release of preformed inflammatory and allergy mediators and de novo synthesis and secretion of cytokines and other compounds. The first biochemicallywell defined step of this signaling cascade is tyrosine phosphorylation of the Fc?RI subunits by Src family kinase Lyn, followed by recruitment and activation of spleen tyrosine kinase (Syk). Activity of Syk is decisive for the formation of multicomponent signaling assemblies, the signalosomes, in the vicinity of the receptors. Formation of the signalosomes is dependent on the presence of transmembrane adaptor proteins (TRAPs). These proteins are characterized by a short extracellular domain, a singletransmembrane domain, and a cytoplasmic tail with various motifs serving as anchors for cytoplasmic signaling molecules. In mast cells five TRAPs have been identified [linker for activation of T cells (LAT), non-T cell activation linker (

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

11.1.

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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