Transmembrane adaptor proteins in the high-affinity IgE receptor signaling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00399709" target="_blank" >RIV/68378050:_____/12:00399709 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fimmu.2011.00095" target="_blank" >http://dx.doi.org/10.3389/fimmu.2011.00095</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2011.00095" target="_blank" >10.3389/fimmu.2011.00095</a>
Alternative languages
Result language
angličtina
Original language name
Transmembrane adaptor proteins in the high-affinity IgE receptor signaling
Original language description
Aggregation of the high-affinity IgE receptor (Fc?RI) initiates a cascade of signaling events leading to release of preformed inflammatory and allergy mediators and de novo synthesis and secretion of cytokines and other compounds. The first biochemicallywell defined step of this signaling cascade is tyrosine phosphorylation of the Fc?RI subunits by Src family kinase Lyn, followed by recruitment and activation of spleen tyrosine kinase (Syk). Activity of Syk is decisive for the formation of multicomponent signaling assemblies, the signalosomes, in the vicinity of the receptors. Formation of the signalosomes is dependent on the presence of transmembrane adaptor proteins (TRAPs). These proteins are characterized by a short extracellular domain, a singletransmembrane domain, and a cytoplasmic tail with various motifs serving as anchors for cytoplasmic signaling molecules. In mast cells five TRAPs have been identified [linker for activation of T cells (LAT), non-T cell activation linker (
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
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Volume of the periodical
2
Issue of the periodical within the volume
11.1.
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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