Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423257" target="_blank" >RIV/68378050:_____/13:00423257 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11010-013-1752-1" target="_blank" >http://dx.doi.org/10.1007/s11010-013-1752-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11010-013-1752-1" target="_blank" >10.1007/s11010-013-1752-1</a>
Alternative languages
Result language
angličtina
Original language name
Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins
Original language description
The TNF-related apoptosis inducing ligand (TRAIL) has promising anti-cancer therapeutic activity, although significant percentage of primary tumors resistant to TRAIL-induced apoptosis remains an obstacle to the extensive use of TRAIL-based mono-therapies. Natural compound curcumin could potentially sensitize resistant cancer cells to TRAIL. We found that the combination of TRAIL with curcumin can synergistically induces apoptosis in three TRAIL-resistant breast cancer cell lines. The mechanism behind this synergistic cell death was investigated by examining an effect of curcumin on the expression and activation of TRAIL-associated cell death proteins. Immunoblotting, RNA interference, and use of chemical inhibitors of TRAIL-activate signaling revealeddifferential effects of curcumin on the expression of Mcl-1 and activities of ERK and Akt. Curcumin-induced production of reactive oxygen species did not affect total expression of DR5 but it enhanced mobilization of DR5 to the plasma me
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Biochemistry
ISSN
0300-8177
e-ISSN
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Volume of the periodical
383
Issue of the periodical within the volume
1-2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
39-48
UT code for WoS article
000325136400005
EID of the result in the Scopus database
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