Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423286" target="_blank" >RIV/68378050:_____/13:00423286 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3892/or.2013.2226" target="_blank" >http://dx.doi.org/10.3892/or.2013.2226</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2013.2226" target="_blank" >10.3892/or.2013.2226</a>

Result language

angličtina

Original language name

Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells

Original language description

Carbonic anhydrase IX (CA IX) is a well-recognized hypoxia marker with promising diagnostic and therapeutic value. CA IX regulates the pH in hypoxic tumor cells and, thereby, contributes to microenvironmental acidosis and cell migration. To gain a betterinsight into the molecular processes driven by CA IX, we performed gene expression profiling of HT-1080 fibrosarcoma cells subjected to CA IX depletion by shRNA silencing. We identified the focal adhesion pathway as being significantly inhibited in theabsence of CA IX and confirmed this finding by functional assays. Thus, we obtained the first direct evidence for the role of CA IX in focal adhesion.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

1147-1153

UT code for WoS article

000314905200040

EID of the result in the Scopus database

—