The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423396" target="_blank" >RIV/68378050:_____/13:00423396 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1182/blood-2012-12-475392" target="_blank" >http://dx.doi.org/10.1182/blood-2012-12-475392</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1182/blood-2012-12-475392" target="_blank" >10.1182/blood-2012-12-475392</a>

Result language

angličtina

Original language name

The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance

Original language description

Granulocyte colony-stimulating factor (Gcsf) drives the proliferation and differentiation of granulocytes, monocytes, and macrophages (m?s) from hematopoietic stem and progenitor cells (HSPCs). Analysis of the zebrafish genome indicates the presence of 2Gcsf ligands, likely resulting from a duplication event in teleost evolution. Although Gcsfa and Gcsfb share low sequence conservation, they share significant similarity in their predicted ligand/receptor interaction sites and structure. Each ligand displays differential temporal expression patterns during embryogenesis and spatial expression patterns in adult animals. To determine the functions of each ligand, we performed loss- and gain-of-function experiments. Both ligands signal through the Gcsf receptor to expand primitive neutrophils and m?s, as well as definitive granulocytes. To further address their functions, we generated recombinant versions and tested them in clonal progenitor assays. These sensitive in vitro techniques ind

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood

ISSN

1528-0020

e-ISSN

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Volume of the periodical

122

Issue of the periodical within the volume

24

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

3918-3928

UT code for WoS article

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EID of the result in the Scopus database

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