An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00435138" target="_blank" >RIV/68378050:_____/13:00435138 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/gb-2013-14-9-r96" target="_blank" >http://dx.doi.org/10.1186/gb-2013-14-9-r96</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/gb-2013-14-9-r96" target="_blank" >10.1186/gb-2013-14-9-r96</a>

Result language

angličtina

Original language name

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse

Original language description

Background: We have used a sensitized ENU mutagenesis screen to produce mouse lines that carry mutations in genes required for epigenetic regulation. We call these lines Modifiers of murine metastable epialleles (Mommes). Results: We report a basic molecular and phenotypic characterization for twenty of the Momme mouse lines, and in each case we also identify the causative mutation. Three of the lines carry a mutation in a novel epigenetic modifier, Rearranged L-myc fusion (Rlf), and one gene, Rap-interacting factor 1 (Rif1), has not previously been reported to be involved in transcriptional regulation in mammals. Many of the other lines are novel alleles of known epigenetic regulators. For two genes, Rlf and Widely-interspaced zinc finger (Wiz), we describe the first mouse mutants. All of the Momme mutants show some degree of homozygous embryonic lethality, emphasizing the importance of epigenetic processes. The penetrance of lethality is incomplete in a number of cases. Similarly, ab

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genome Biology

ISSN

1465-6906

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

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UT code for WoS article

000328195700002

EID of the result in the Scopus database

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