The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F14%3A00431703" target="_blank" >RIV/68378050:_____/14:00431703 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/14:10317654
Result on the web
<a href="http://dx.doi.org/10.1242/jcs.155838" target="_blank" >http://dx.doi.org/10.1242/jcs.155838</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/jcs.155838" target="_blank" >10.1242/jcs.155838</a>
Alternative languages
Result language
angličtina
Original language name
The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity
Original language description
The nuclear SMN complex localizes to specific structures called nuclear gems. The loss of gems is a cellular marker for several neurodegenerative diseases. Here, we identify that the U1-snRNP-specific protein U1-70K localizes to nuclear gems, and we showthat U1-70K is necessary for gem integrity. Furthermore, we show that the interaction between U1-70K and the SMN complex is RNA independent, and we map the SMN complex binding site to the unstructured N-terminal tail of U1-70K. Consistent with these results, the expression of the U1-70K N-terminal tail rescues gem formation. These findings show that U1-70K is an SMN-complex-associating protein, and they suggest a new function for U1-70K in the formation of nuclear gems.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP302%2F11%2F1910" target="_blank" >GAP302/11/1910: Formation of splicing machinery in the context of the cell nucleus</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cell Science
ISSN
0021-9533
e-ISSN
—
Volume of the periodical
127
Issue of the periodical within the volume
18
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
3909-3915
UT code for WoS article
000342357900005
EID of the result in the Scopus database
—