Renaissance of mammalian endogenous RNAi

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F14%3A00434358" target="_blank" >RIV/68378050:_____/14:00434358 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.febslet.2014.05.030" target="_blank" >http://dx.doi.org/10.1016/j.febslet.2014.05.030</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.febslet.2014.05.030" target="_blank" >10.1016/j.febslet.2014.05.030</a>

Result language
angličtina
Original language name
Renaissance of mammalian endogenous RNAi
Original language description
RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA). RNAi is an ancient eukaryotic defense mechanism against viruses and mobile elements. In mammals, endogenous RNAi was outstripped during evolution by the current innate and acquired immunity. The RNAi apparatus, which remains essentially intact, serves mostly the microRNA pathway, which regulates endogenous gene expression. Remarkably, several recent publications brought the mammalian endogenous RNAi pathway back into the spotlight. Here, I will provide an up-to-date review of the mammalian endogenous RNAi pathway with a focus on its defensive role and overlaps with miRNA and piRNA pathways.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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