RNAi and miRNA pathways in mammals I - molecular mechanisms.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523485" target="_blank" >RIV/68378050:_____/19:00523485 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
RNAi and miRNA pathways in mammals I - molecular mechanisms.
Original language description
RNA silencing denotes sequence-specific repression mediated by small RNAs. In mammals, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression. It has been implicated in many biological processes and majority of mammalian genes appear to be directly or indirectly exposed to miRNA-mediated regulations. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements, although it occasionally also acquired function in protein-coding gene regulation. The function of RNAi in mammals is still poorly understood but it is clear that proteins supporting RNAi are also involved in miRNA biogenesis and function. Because of the volume of information, the review of mammalian miRNA and RNAi pathways was divided into two parts, where first one presented here reviews components of the pathways and the second one reviews function and significance of the pathways
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
<a href="/en/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: National infrastructure for chemical biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Introduction to RNAi and miRNA pathways
ISBN
978-80-246-4372-4
Number of pages of the result
54
Pages from-to
1-339
Number of pages of the book
339
Publisher name
Karolinum
Place of publication
Praha
UT code for WoS chapter
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