DISP3 promotes proliferation and delays differentiation of neural progenitor cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F14%3A00436399" target="_blank" >RIV/68378050:_____/14:00436399 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.febslet.2014.09.036" target="_blank" >http://dx.doi.org/10.1016/j.febslet.2014.09.036</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.febslet.2014.09.036" target="_blank" >10.1016/j.febslet.2014.09.036</a>

Result language
angličtina
Original language name
DISP3 promotes proliferation and delays differentiation of neural progenitor cells
Original language description
DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. In the present study we used a multipotent cerebellar progenitor cell line, C17.2, to investigate the impact of DISP3 on the proliferation and differentiation of neural precursors. We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. Finally, the differentiation profile of DISP3-expressing cells was altered, as evidenced by delayed expression of neural specific markers and a reduced capacity to undergo neural differentiation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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