SART3-Dependent Accumulation of Incomplete Spliceosomal snRNPs in Cajal Bodies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00442411" target="_blank" >RIV/68378050:_____/15:00442411 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/15:43900532

Result on the web

<a href="http://dx.doi.org/10.1016/j.celrep.2014.12.030" target="_blank" >http://dx.doi.org/10.1016/j.celrep.2014.12.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.celrep.2014.12.030" target="_blank" >10.1016/j.celrep.2014.12.030</a>

Result language

angličtina

Original language name

SART3-Dependent Accumulation of Incomplete Spliceosomal snRNPs in Cajal Bodies

Original language description

Cajal bodies (CBs) are evolutionarily conserved nuclear structures involved in the metabolism of spliceosomal small nuclear ribonucleoprotein particles (snRNPs). CBs are not present in all cell types, and the trigger for their formation is not yet known.Here, we depleted cells of factors required for the final steps of snRNP assembly and assayed for the presence of stalled intermediates in CBs. We show that depletion induces formation of CBs in cells that normally lack these nuclear compartments, suggesting that CB nucleation is triggered by an imbalance in snRNP assembly. Accumulation of stalled intermediates in CBs depends on the di-snRNP assembly factor SART3. SART3 is required for both the induction of CB formation as well as the tethering of incomplete snRNPs to coilin, the CB scaffolding protein. We propose a model wherein SART3 monitors tri-snRNP assembly and sequesters incomplete particles in CBs, thereby allowing cells to maintain a homeostatic balance of mature snRNPs in the

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Reports

ISSN

2211-1247

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

429-440

UT code for WoS article

000348202500011

EID of the result in the Scopus database

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