Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00442565" target="_blank" >RIV/68378050:_____/15:00442565 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/cbic.201402662" target="_blank" >http://dx.doi.org/10.1002/cbic.201402662</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbic.201402662" target="_blank" >10.1002/cbic.201402662</a>

Result language
angličtina
Original language name
Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization
Original language description
A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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