Substrate recognition and function of the R2TP complex in response to cellular stress
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00442681" target="_blank" >RIV/68378050:_____/15:00442681 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fgene.2015.00069" target="_blank" >http://dx.doi.org/10.3389/fgene.2015.00069</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fgene.2015.00069" target="_blank" >10.3389/fgene.2015.00069</a>
Alternative languages
Result language
angličtina
Original language name
Substrate recognition and function of the R2TP complex in response to cellular stress
Original language description
The R2TP complex is a HSP90 co-chaperone, which consists of four subunits: PIH1D1, RPAP3, RUVBL1, and RUVBL2. It is involved in the assembly of large protein or protein-RNA complexes such as RNA polymerase, small nucleolar ribonucleoproteins (snoRNPs), phosphatidylinositol 3 kinase-related kinases (PIKKs), and their complexes. While RPAP3 has a HSP90 binding domain and the RUVBLs comprise ATPase activities important for R2TP functions, PIH1D1 contains a PIH-N domain that specifically recognizes phosphorylated substrates of the R2TP complex. In this review we provide an overview of the current knowledge of the R2TP complex with the focus on the recently identified structural and mechanistic features of the R2TP complex functions. We also discuss the wayR2TP regulates cellular response to stress caused by low levels of nutrients or by DNA damage and its possible exploitation as a target for anti-cancer therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in genetics
ISSN
1664-8021
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
February 2015
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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